The Proteomics and Fibromyalgia: A Perspective on the Study of the Inflammatory Response in Fibromyalgia

Fibromyalgia (FM) is a chronic, non-degenerative disease characterized by widespread and sustained pain, sleep disturbances, physical exhaustion, cognitive difficulties. The FM pathophysiology has not been completely clarified, several theories have postulated, among which the dysregulation of inflammatory response as mediator painful phenomenon. In addition, it reported that patients present rise IL-6 IL-8 serum levels; this fact clinical relevance since these molecules induce symptoms such fatigue, hyperalgesia, allodynia. Additionally, some studies carried out on participation leukocytes in physiopathology fibromyalgia; evidence suggests mast cells are most relevant they promote release pro-inflammatory cytokines to stimuli substance P or corticotropin-releasing hormone, were elevated patients. number increasing year after around world. For reason, essential study proteins involved fibromyalgia. Proteomic analysis techniques tandem mass tag (TMT) with isobaric labeling offer hope find biological markers allow simultaneously multiple patients, allowing identification biomarkers. Thus, use tagging will shortly expand knowledge fibromyalgia, helping identify biomarkers improve diagnosis increase quality life their families.